Letrozol 2,5 mg
Ny2.5 mg · 50 tablets · Letrozole 2.5 mg delivers irreversible aromatase suppression for estrogen-blocking, testosterone-enhancing, and PCT-focused research — with strong PK profile and long-lasting endocrine modulation.
€ 39.00
Beskrivning
Letrozole 2.5 mg
Varumärke: Magnus Läkemedel
Innehåll: 50 tablets | 2.5 mg per tablet
Pris: €39
Tillverkad i: Europa
🧪 Produktöversikt
Letrozole 2.5 mg is a third-generation, non-steroidal aromatase inhibitor (AI) that irreversibly binds the CYP19 enzyme to suppress estrogen biosynthesis. Designed for advanced hormone modulation studies, it supports research into testosterone enhancement, post-cycle therapy (PCT), fertility pathways, and estrogen-receptor positive (ER+) tumor models.
A single 2.5 mg oral dose reduces serum estradiol (E₂) by 60–80% within 24 hours and maintains suppression for ≥48 hours, supported by a 42–48 hour mean half-life. In male models, letrozole increases LH, FSH, and endogenous testosterone while improving sperm count—without impacting adrenal androgens. Exposure is prohibited in all WADA-sanctioned settings.
✅ Viktiga forskningsresultat
Potent estrogen suppression:
≥80% reduction in serum estradiol (E₂) achieved within 24 h after 2.5 mg dosing [NCBI]
Endogenous testosterone boost:
Studies in male infertility show ↑ LH, FSH, T, and sperm quality after 8–16 weeks [ScienceDirect, PMC]
Pharmacokinetics:
Oral bioavailability ~100%, t½ ≈ 42–48 h, steady-state in 2–6 weeks [DrugBank, PMC]
Common side effects:
Hot-flushes, joint discomfort, fatigue, and menopausal-like symptoms [NHS, Breast Cancer Now]
Long-term risks:
Reductions in bone-mineral density and lipid imbalances documented in chronic protocols [PMC]
🧬 Föreslagna laboratorieapplikationer
-
Aromatase inhibition and estrogen suppression modeling
-
Testosterone recovery and hormonal modulation
-
Fertility enhancement trials in male hypogonadism
-
PCT protocols in anabolic research models
-
ER+ breast cancer resistance pathways (e.g. tamoxifen-resistant models)
📊 Tekniska specifikationer
| Fält | Uppgifter |
|---|---|
| Kemiskt namn | Letrozole |
| Kemisk formel | C<sub>17</sub>H<sub>11</sub>N<sub>5</sub> |
| Synonymer | Femara, CGP 57148, 4,4′-((1H-1,2,4-triazol-1-yl)methylene)dibenzonitrile |
| Molekylvikt | 285.3 g/mol |
| CAS-nummer | 112809-51-5 |
| Halveringstid | 42–48 hours |
| Detektionsfönster | ≥2 days (varies by protocol) |
| Dokumenterade fördelar | ↓ estrogen ≥80%, ↑ LH/FSH, ↑ T, fertility support, anti-ER+ tumor adjunct |
| Huvudsakliga risker | ↓ BMD, joint pain, lipid alterations, fatigue, menopausal symptoms |
| Total aktiv förening | 125 mg per carton (2.5 mg × 50 tablets) |
| Hållbarhetstid | 36 månader (tillverkarens specifikation) |
❄️ PubChem-stödda forskningsinsikter
-
Irreversibly inhibits aromatase enzyme (CYP19)
-
Maintains ≥80% estradiol suppression for 48+ hours
-
Improves testosterone-to-estradiol ratio without adrenal disruption
-
Increases LH and FSH in male fertility research
-
Used as an adjunct in tamoxifen-resistant ER+ tumor protocols
⚠️ Dokumenterad forskning Biverkningar
-
Hot flashes and joint discomfort common
-
Potential for bone-density loss with chronic use
-
Altered lipid profiles: ↑ LDL / ↓ HDL
-
Fatigue and hormonal mood shifts
-
High doping detectability under WADA S4 classification
🧯 Hantering & efterlevnad
Endast för forskningsändamål - Ej för human- eller veterinärmedicinsk användning
Butik på 15-25 °C, protect from light and moisture
Köpbekräftelser kvalificerad forskare status
Listad på WADA:s förbjudna lista S4 — any exposure may yield a positive doping result
Det finns inga recensioner ännu.
