Description

Testo P 150 – Testosterone Propionate (Royal Pharmaceuticals)

Category: Injectable Testosterone Ester (Research Only)
Brand: Royal Pharmaceuticals
Concentration: 150 mg/ml testosterone propionate
Packing: 10 × 1 ml ampoules
Origin: United Kingdom
Price: €39

Research Notice: Laboratory, analytical and collector use only. Not for human or veterinary administration.

🧪 What Is Testosterone Propionate?

Testosterone propionate is a short-chain ester of testosterone (testosterone 17β-propanoate).
It acts as a rapid-release pro-drug, hydrolysed quickly to free testosterone after intramuscular depot formation.

Because of its fast kinetics, it is widely used in:

• Androgen receptor (AR) signalling research
• Short-duration pharmacokinetic modelling
• Anti-doping analytical calibration (LC-MS/MS, GC-MS)
• Comparative studies of short- vs long-acting testosterone esters

This profile describes the compound only as a scientific reference material.

🔬 Mechanism of Action

1. Rapid Ester Cleavage

The three-carbon propionate ester produces a short depot effect.
Free testosterone is rapidly released and enters AR-responsive tissues.

2. Androgen Receptor Activation

• Transcription of androgen-regulated genes
• Enhanced protein synthesis and nitrogen retention
• Stimulation of erythropoiesis
• Maintenance of androgen-dependent physiological pathways

3. Metabolic Pathways

• Reduction to dihydrotestosterone (DHT)
• Aromatisation to estradiol (E2)

4. Pharmacokinetic Characteristics

Elimination half-life is approximately 0.8–2 days, making it one of the fastest-acting testosterone esters used in research and historical clinical settings.

📚 Research Applications

• Short-acting androgen reference compound
• Release-rate modelling vs longer esters (E, C, U)
• Control substance for steroid detection systems
• In-vitro androgen receptor activity assays
• Endocrine pathway comparison studies

📈 Potential Research-Level Observations

• Rapid rise in androgen levels following ester cleavage
• Marked fluctuations in exposure curve compared to long esters
• Clear metabolite profile useful for analytical method development
• Short-interval AR stimulation patterns

⚠️ Safety Profile & Known Risks (Class Effects)

Androgenic

• Acne, seborrhoea
• Accelerated androgenic alopecia
• Virilisation if exposed in females

Endocrine Suppression

• Reduced LH/FSH secretion
• Lower endogenous testosterone
• Impaired fertility or testicular atrophy in prolonged exposure models

Cardiometabolic

• HDL reduction / LDL increase
• Possible elevation in blood pressure

Injection-Related

• Common local pain (propionate esters often sting)
• Inflammation or irritation
• Risk of abscess with improper handling

Toxicological Notes

Safety Data Sheets classify testosterone propionate as:

• Carcinogenic (Category 1A)
• Reproductive toxicant (Category 2)
• Harmful if swallowed, inhaled, or in contact with skin
• Very toxic to aquatic environments

🛑 Compliance & Legal Status

• Controlled substance in many jurisdictions
• WADA S1 – prohibited at all times
• Analytical laboratories must follow institutional safety and storage protocols
• Not a dietary supplement, medication or consumer product

📊 Technical Data Table

For research and analytical use only. Not for human or veterinary administration.