Description
Exemestane 25 mg
Brand: Magnus Pharmaceuticals
Content: 30 tablets | 25 mg per tablet
Price: €38
Manufactured in: Europe
🧪 Product Overview
Exemestane 25 mg is a third-generation, steroidal aromatase inhibitor (AI) that irreversibly binds the CYP19 enzyme, producing sustained suppression of systemic estrogen. Widely used in hormonal modulation and post-cycle therapy (PCT) research, it is particularly effective for testosterone-boosting protocols and estrogen-dependent tumor investigations.
A single 25 mg dose lowers estradiol by 60–80% within 12 hours and sustains suppression for up to 48 hours due to its ~24–27 hour half-life. Studies confirm its effectiveness in raising LH, FSH, and modestly increasing endogenous testosterone without altering adrenal androgens. This compound is listed on WADA’s S4 prohibited list for hormone modulators.
✅ Key Research Highlights
Irreversible aromatase blockade:
Covalently deactivates CYP19, maintaining estrogen suppression post-clearance [ScienceDirect]
24-hour pharmacokinetics:
Half-life of 24–27 hours ensures stable once-daily dosing in long-term hormonal protocols [PubMed]
↑ Testosterone-to-estradiol ratio:
25 mg/day improved T:E ratios in male models without affecting DHEA/androstenedione [FDA data]
Bone & lipid impact (chronic use):
Long-term data show ↓ BMD and HDL↓ / LDL↑ — relevant for extended-duration studies [PubMed, PMC]
Shelf-stable & lab-friendly:
Film-coated tablets remain potent at ≤25 °C without refrigeration [ICH Stability, MSDS]
🧬 Suggested Laboratory Applications
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Irreversible aromatase inhibition and estrogen-suppression modeling
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Testosterone enhancement in male hypogonadism models
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PCT studies for anabolic-recovery protocols
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LH/FSH modulation research
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Tamoxifen-resistant estrogen-tumor studies
📊 Technical Specifications
| Field | Data |
|---|---|
| Chemical Name | Exemestane (INN) |
| Chemical Formula | C<sub>20</sub>H<sub>24</sub>O<sub>2</sub> |
| Synonyms | Aromasin; FCE 24304; 6-methyleneandrosta-1,4-diene-3,17-dione |
| Molecular Weight | 296.4 g/mol |
| CAS Number | 107868-30-4 |
| Half-life | ~24–27 hours |
| Detection Window | Medium-long, varies with protocol |
| Documented Benefits | ↓ E2 by 60–80%, ↑ LH/FSH, ↑ T, stable estrogen suppression |
| Main Risks | ↓ BMD, lipid shifts, fatigue, joint pain, hot flashes |
| Total Active Compound | 750 mg per carton (25 mg × 30 tablets) |
| Shelf-life | 36 months (manufacturer specification) |
❄️ PubChem-Supported Research Insights
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Irreversible suppression of estrogen via steroidal aromatase inhibition
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Rapid E2 reduction within 12 hours of dosing
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Increases T:E ratio in male subjects without disturbing adrenal steroids
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Maintains hormonal control for up to 48 hours post-dose
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Applied in resistant ER+ tumor model studies and androgen support trials
⚠️ Documented Research Side Effects
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Common: Hot-flushes, arthralgia, fatigue, insomnia
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Long-term: Bone mineral density reduction, HDL↓/LDL↑
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Other: Menopausal symptoms and mood variations
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Listed under WADA S4 — prohibited in all competitive levels
🧯 Handling & Compliance
For Research Use Only — Not for human or veterinary use
Store at 15–25 °C, protect from light and moisture
Purchase confirms qualified researcher status
Listed on WADA Prohibited List S4 — any exposure may result in a positive test
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Exémestane 25 mg – Équilibre hormonal et gains musculaires
Je prends 25 mg d’exémestane pour réguler mon taux d’œstrogènes pendant mes cycles. Cela m’a permis de maintenir ma masse musculaire, de réduire la rétention d’eau et de consolider mes gains, tout en favorisant un équilibre hormonal global.
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Zufriedenstellender Kauf
Ich habe Exemestan 25 mg bei CandyGym bestellt und alles verlief reibungslos. Die Bestellung kam pünktlich und gut verpackt an, und das Produkt machte einen authentischen Eindruck. Es entsprach der Beschreibung und bot ein gutes Preis-Leistungs-Verhältnis.
