Descrizione

Salbutamol 4 mg Tablets — Swiss Remedies

Marchio: Rimedi svizzeri
Categoria: β2-Adrenergic Research Compound
Contenuto: 100 tablets × 4 mg (400 mg total)
Prezzo: €39
Prodotto in: Svizzera

🧪 Panoramica del prodotto

Salbutamol (USAN: albuterol) is a short-acting, selective β2-adrenergic receptor agonist used
in laboratories as a reference bronchodilator and β2-selectivity probe. It relaxes airway
smooth muscle via β2-receptor activation, cAMP elevation, and PKA-mediated reduction of intracellular calcium.
Because of its well-defined pharmacology, salbutamol is a core comparator in respiratory and receptor-target
studies.

✅ Key Research Highlights

β2-agonist benchmark:
Canonical reference for bronchodilation, cAMP signaling, β2-selectivity, and smooth-muscle physiology studies.

Exercise physiology & anti-doping relevance:
Controlled studies show no performance improvement in non-asthmatic athletes at inhaled doses up to
1600 μg/24 h (JSSM). Used extensively in anti-doping pharmacokinetics research.

WADA compliance modeling:
WADA permits only inhaled salbutamol ≤1600 μg/24 h; oral/systemic administration is prohibited.
Urinary threshold: ~1000 ng/mL (S3 Beta-2 Agonists).

🧬 Suggested Laboratory Applications

• β2-receptor pharmacology assays
• Bronchodilator response and smooth-muscle relaxation studies
• cAMP/PKA signaling models
• Receptor selectivity and structure-activity analyses
• Anti-doping threshold and detection research

📊 Technical Specifications

❄️ Mechanism of Action (Laboratory Context)

Activation of β2-receptors (G_s-coupled) → stimulation of adenylyl cyclase →
↑ cAMP → PKA activation → reduced intracellular Ca²⁺ & MLCK activity → smooth-muscle relaxation
and bronchodilation.

⚠️ Documented Research Side Effects

• Tremor and fine-muscle activation
• Tachycardia and palpitations (β1 spillover at higher doses)
• Hypokalemia via β2-mediated potassium shift
• Lactic acidosis in high systemic exposures
• Hyperglycemia and metabolic shifts
• Rare hypersensitivity reactions reported in clinical labeling

🧯 Handling & Compliance

Solo per uso di ricerca — not a medicine, supplement, or veterinary product.
Buyer affirms qualified laboratory use and compliance with institutional SOPs and local regulations.
Salbutamol is regulated under WADA S3 Beta-2 Agonists; systemic/oral use is prohibited without a TUE.