Description

Tamoxifen 10 mg

Marque : Magnus Pharmaceuticals
Contenu : 100 tablets | 10 mg per tablet
Prix : €29
Fabriqué en : L'Europe

🧪 Aperçu du produit

Tamoxifen 10 mg delivers a high-purity selective estrogen receptor modulator (SERM) used extensively in both endocrine and androgen-focused research. By binding to ER-α/β receptors and blocking estrogen-mediated feedback on the hypothalamic–pituitary–gonadal (HPG) axis, tamoxifen promotes a cascade increase in LH, FSH, and endogenous testosterone in male models.

In female models, it remains the gold-standard anti-estrogen for ER-positive tumor protocols. Its high oral bioavailability (~100%) and long half-life (4–11 days for parent, up to 70 hours for active metabolite endoxifen) support once-daily use in long-range studies, including PCT, fertility, gynecomastia reversal, and hormone-modulation assays.

✅ Principaux résultats de la recherche

HPG-axis stimulation:
10–20 mg/day for 3 months doubled serum testosterone in hypogonadal males [PMC]

Gynecomastia control:
Clinical data show significant breast tissue regression in AAS-using males on 10–20 mg/day

Anti-estrogen benchmark:
First-line SERM for ER+ breast cancer research and comparative estrogen-blocking trials [NCBI]

Pharmacokinetics:
~100% oral bioavailability; 4–11 day half-life (parent), 50–70 hours (endoxifen metabolite) [Wikipedia]

Storage & stability:
Film-coated tablets stable ≤25 °C with 36-month shelf-life — ideal for long-term protocols [PubChem, PubMed]

🧬 Applications suggérées en laboratoire

HPG-axis and testosterone recovery models
Gynecomastia reversal and estrogenic side-effect prevention
SERM benchmarking in ER-positive breast-cancer assays
Post-cycle therapy research for anabolic models
Hormone-modulation pharmacokinetics

📊 Spécifications techniques

Champ d'application	Données
Nom chimique	Tamoxifen (base); supplied as Tamoxifen Citrate
Formule chimique	C<sub>26</sub>H<sub>29</sub>NO (base)
Synonymes	Nolvadex; TMX; 4-(1-dimethylaminoethoxy)-diphenyl-1-ethenyl-phenol
Poids moléculaire	371.5 g/mol (base); 563.6 g/mol (citrate)
Numéro CAS	10540-29-1 (base); 54965-24-1 (citrate)
Demi-vie	Parent: 4–11 days · Endoxifen: 50–70 hours
Fenêtre de détection	Long-acting — detectable for several weeks
Avantages documentés	↑ LH/FSH, ↑ testosterone, ↓ gynecomastia, SERM gold standard
Principaux risques	Hot-flushes, ↓ bone density, cataract risk, thrombo-embolism, lipid shifts
Composé actif total	1,000 mg tamoxifen base per carton (10 mg × 100 tablets)
Durée de conservation	36 months (manufacturer specification)

❄️ Perspectives de recherche soutenues par PubChem

Blocks estrogen feedback to HPG axis → ↑ endogenous testosterone
Used clinically in both male infertility and female ER+ oncology
Demonstrated ability to reverse steroid-induced gynecomastia
Maintains receptor suppression up to 6 weeks post-use
Oral form preferred over injectable SERMs for logistical ease

⚠️ Effets secondaires documentés par la recherche

Hot-flushes, fatigue, and temporary visual disturbances
Lipid profile changes (↑ LDL / ↓ HDL) with long-term use
Thrombo-embolic events in susceptible models
Cataract formation risk at extended exposure
Reduced bone-mineral density (BMD) with prolonged protocols

🧯 Manipulation et conformité

Réservé à la recherche — Not for human or veterinary use
Store at 15–25°C, protect from light and moisture
Purchase confirms qualified researcher status
Inscrit sur la liste WADA Prohibited List S4 (Hormone Modulators) — any exposure may trigger positive test