Description

Salbutamol 4 mg Tablets — Swiss Remedies

Marque : Remèdes suisses
Catégorie : β2-Adrenergic Research Compound
Contenu : 100 tablets × 4 mg (400 mg total)
Prix : €39
Fabriqué en : Switzerland

🧪 Aperçu du produit

Salbutamol (USAN: albuterol) is a short-acting, selective β2-adrenergic receptor agonist used
in laboratories as a reference bronchodilator and β2-selectivity probe. It relaxes airway
smooth muscle via β2-receptor activation, cAMP elevation, and PKA-mediated reduction of intracellular calcium.
Because of its well-defined pharmacology, salbutamol is a core comparator in respiratory and receptor-target
studies.

✅ Principaux résultats de la recherche

β2-agonist benchmark:
Canonical reference for bronchodilation, cAMP signaling, β2-selectivity, and smooth-muscle physiology studies.

Exercise physiology & anti-doping relevance:
Controlled studies show no performance improvement in non-asthmatic athletes at inhaled doses up to
1600 μg/24 h (JSSM). Used extensively in anti-doping pharmacokinetics research.

WADA compliance modeling:
WADA permits only inhaled salbutamol ≤1600 μg/24 h; oral/systemic administration is prohibited.
Urinary threshold: ~1000 ng/mL (S3 Beta-2 Agonists).

🧬 Applications suggérées en laboratoire

β2-receptor pharmacology assays
Bronchodilator response and smooth-muscle relaxation studies
cAMP/PKA signaling models
Receptor selectivity and structure-activity analyses
Anti-doping threshold and detection research

📊 Spécifications techniques

Champ d'application	Données
Nom chimique	Salbutamol (Albuterol)
Chemical Formula (base)	C₁₃H₂₁NO₃
Molecular Weight (base)	239.31 g/mol
CAS Numbers	Base: 18559-94-9; Sulfate: 51022-70-9
Class / Target	Short-acting β2-adrenergic receptor agonist (β2AR)
Strength / Pack	4 mg per tablet × 100 tablets (400 mg total)
Storage	Store dry, cool, and protected from light; follow SDS
Shelf-Life	36 months (per COA/label)

❄️ Mechanism of Action (Laboratory Context)

Activation of β2-receptors (G_s-coupled) → stimulation of adenylyl cyclase →
↑ cAMP → PKA activation → reduced intracellular Ca²⁺ & MLCK activity → smooth-muscle relaxation
and bronchodilation.

⚠️ Effets secondaires documentés par la recherche

Tremor and fine-muscle activation
Tachycardia and palpitations (β1 spillover at higher doses)
Hypokalemia via β2-mediated potassium shift
Lactic acidosis in high systemic exposures
Hyperglycemia and metabolic shifts
Rare hypersensitivity reactions reported in clinical labeling

🧯 Manipulation et conformité

Réservé à la recherche — not a medicine, supplement, or veterinary product.
Buyer affirms qualified laboratory use and compliance with institutional SOPs and local regulations.
Salbutamol is regulated under WADA S3 Beta-2 Agonists; systemic/oral use is prohibited without a TUE.